Sympathetic activity is lower in rats fed a high fat diet than in rats fed a high carbohydrate diet under pair-feeding condition.

Accession number;00A0428642
Title;Sympathetic activity is lower in rats fed a high fat diet than in rats fed a high carbohydrate diet under pair-feeding condition.
Author; MATSUO T (Kagawa Univ., Kagaga-ken, Jpn)
Journal Title;Technical Bulletin of Faculty of Agriculture, Kagawa University
Journal Code:G0765A
ISSN:0368-5128
VOL.52;NO.;PAGE.43-47(2000)
Figure&Table&Reference;FIG.1, TBL.2, REF.26
Pub. Country;Japan
Language;English
Abstract;Effects of a high fat diet compared with a high carbohydrate diet on sympathetic activity and body fat accumulation were studied in rats. Rats were meal-fed an isoenergetic diet based on either fat or carbohydrate for 8 weeks. Body weight gain, abdominal adipose tissue weight and carcass fat content were significantly greater (p<0.05) in the high fat diet group than in the high carbohydrate diet group. Basal norepinephrine content in interscapular brown adipose tissue was significantly lower (p<0.05) in the high fat diet group than in the high carbohydrate diet group, but contents in heart and pancreas were almost the same between the two dietary groups. Norepinephrine turnover rates in the high fat diet group were significantly lower (p<0.05) in interscapular brown adipose tissue, heart, and pancreas as compared with rates in the high carbohydrate diet group. These results suggest that the high fat diet promotes body fat accumulation by reducing sympathetic activity as compared with intake of the high carbohydrate diet. (author abst.)