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Accession number;99A1042710
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| Title;Application of SPECT to psychiatry. |
| Author;
MATSUDA HIROSHI
(Natl. Center Hosp. for Ment., Nerv. and Muscular Disord.)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.132;PAGE.1-13(1999)
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| Figure&Table&Reference;FIG.7, REF.40 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Brain perfusion SPECT using 99mTc-ethyl-cysteinate dimer(99mTc-ECD)was applied to psychiatric diseases with aid of statistical parametric mapping(SPM) for analysis of data. To evaluate influence of aging on brain perfusion, noninvasive measurements of cerebral blood flow using 99mTc-ECD were performed in 53 normal volunteers, aged 18 to 87 years old. Mean cerebral blood flow (mCBF) was 43.9.+-. 5.0ml/100g/min and showed weak negative correlation with aging (r=0.451). Perisylvian cerebral cortices and medial frontal areas including anterior cingulate gyri showed greater negative correlation than other areas. These findings suggest the necessity of age-matched control regional CBF(rCBF) data to investigate rCBF abnormality in patients. Four drug-naive schizophrenic patients showed flow decrease in bilateral frontal and superior temporal areas and a left infero-posterior temporal area. Haloperidol administration induced flow decrease in bilateral frontal and left parietal areas, while flow increase in bilateral striatal and right hippocampal areas. Ten aged depressive patients showed flow decrease in bilateral frontal and left temporo-parietal areas. Even after remission patients showed flow decrease in the left frontal area as compared with normal subjects. Remission induced flow increase in the right frontal, right parietal, and right orbitofrontal areas compared with depression. These results suggest that CBF measurements using 99mTc-ECD were useful for objective evaluation of regional abnormality in brain function in psychiatric diseases. |
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