Clinical Application of Cardiac SPECT.
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Accession number;99A1042715
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| Title;Clinical Application of Cardiac SPECT. |
| Author;
NISHIMURA SHIGEYUKI
(Yokohama Rosai Hosp.)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.132;PAGE.41-49(1999)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Single-photon emission computed topography (SPECT) has replaced planar imaging techniques for myocardial scintigraphy. Thallium-201 was the dominant agent employed for myocardial perfusion imaging. Today new technetium-99m labeled radionuclides have been used as excellent alternatives to 201T1 for detection of coronary artery disease, prognostification, and even assessment of myocardial viability. Pharmacologic stress imaging using either dipyridamole, adenosine or dobutamine is a substitute for exercise stress. Accurate determination of myocardial viability is vitally important for clinical decision making for patients with LV dysfunction who will most benefit from revascularization. Stunned and hibernated myocardium may result in profound regional LTV dysfunction in absence of necrosis. The various approach such as stress-redistribution-reinjection imaging, rest-redistribution imaging and stress-redistribution-24 hours delayed imaging has been utilized to assess myocardial viability with 201T1. Quantitative assessment of 99mTc MIBI uptake reflect the degree of viability. 123I-Metaiodobenzylguanidine (MIBG), an analog of norepinephrine, has been used for scintigraphic assessment of regional cardiac adrenergic innervation. Cardiac sympathetic denervation, assessed by 123I-MIBG, due to ischemia in non-Q myocardial infarction and unstable angina has been shown. Quantitative cardiac MIBG scintigram was shown to have prognostic value in patients with severe congestive heart failure 123I-BMIPP(.RHO.-methyl-iodophenyl pentadecanoic acid) has been used to assess myocardial fatty acid utilization. BMIPP has the memory function of ischemia in unstable angina, since myocardial fatty acid decreased BMIPP uptake persists several days after ischemic episode.... (author abst.) |
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