Physiologic significance of nitric oxide and endothelin-1 in circulatory adaptation.
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Accession number;00A0259389
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| Title;Physiologic significance of nitric oxide and endothelin-1 in circulatory adaptation. |
| Author;
ENDO A
(Nihon Univ. School Of Medicine, Tokyo, Jpn)
AYUSAWA M
(Nihon Univ. School Of Medicine, Tokyo, Jpn)
MINATO M
(Nihon Univ. School Of Medicine, Tokyo, Jpn)
TAKADA M
(Nihon Univ. School Of Medicine, Tokyo, Jpn)
TAKAHASHI S
(Nihon Univ. School Of Medicine, Tokyo, Jpn)
HARADA K
(Nihon Univ. School Of Medicine, Tokyo, Jpn)
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Journal Title;Pediatr Int
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Journal Code:Z0373B
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ISSN:1328-8067
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VOL.42;NO.1;PAGE.26-30(2000)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.30 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Background: The purpose of the present paper was to evaluate the physiologic significance of nitric oxide (NO) and endothelin (ET)-1 in circulatory adaptation in the neonate. Methods: The serum levels of NO metabolites (NOx; the sum of nitrites and nitrates) and the plasma level of ET-1 were determined in 14 healthy full-term infants at 0-6 h, 24 h and 5 days after birth. We measured the heart rate, the mean systemic blood pressure and the mean pulmonary arterial pressure, estimated by pulsed Doppler echocardiography, at each time point. Results: The serum concentration of NOx was lowest at birth and increased with age. The plasma concentration of ET-1 was highest at birth and decreased with age. The ratio of NOx to ET-1 was inversely related to the estimated mean pulmonary arterial pressure in the early neonatal period. The ratio of NOx to ET-1 was not correlated with the systemic blood pressure. Conelusion: Increased NO synthesis and decreased production of ET-1 during the early neonatal period may contribute to the decrease in pulmonary arterial pressure. (author abst.) |
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