Reiationship of insulin-like growth factor-I, insulin-like growth factor binding protein-3, insulin, growth hormone in cord blood and maternal factors with birth height and birthweight.
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Accession number;00A0259390
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| Title;Reiationship of insulin-like growth factor-I, insulin-like growth factor binding protein-3, insulin, growth hormone in cord blood and maternal factors with birth height and birthweight. |
| Author;
YANG S W
(Seoul National Univ. Coll. Medicine, Seoul, Kor)
YU J S
(Seoul National Univ. Coll. Medicine, Seoul, Kor)
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Journal Title;Pediatr Int
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Journal Code:Z0373B
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ISSN:1328-8067
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VOL.42;NO.1;PAGE.31-36(2000)
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| Figure&Table&Reference;FIG.4, TBL.2, REF.27 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Background: To determine whether the following factors are related to birthweight or birth height, we measured insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein (IGFBP)-3, insulin and growth hormone (GH) levels in cord blood and also observed the relationship between birthweight, birth height and maternal factors. Methods: One hundred and ninety-four cord bloods were collected, 106 from males and 88 from females. Three newborns were small for gestational age (SGA), 168 were appropriate (AGA) and 23 were large (LGA); 21 newborns were preterm and 172 were term. Results: Levels of IGF-I and IGFBP-3, measured by enzyme-linked immunosorbent assay, were significantly lower in preterm babies (35.3 .+-. 15.1 and 1025.6 .+-. 562.8 ng/mL, respectively) than in term babies (61.6 .+-. 39.5 and 1252.6 .+-. 403.2 ng/mL, respectively; P < 0.01), but neither insulin nor GH levels, measured by radioimmunoassay, showed any significant difference between the two groups (P > 0.05). Among term babies, IGF-I and IGFBP-3 levels were significantly higher in the LGA group (96. .+-. 34.1 and 1544.7 .+-. 418.1 ng/mL, respectively) than in the AGA group (56.4 .+-. 37.6 and 1212.8 .+-. 383.4 ng/mL, respectively; P < 0.01). Levels of IGF-I and IGFBP-3 showed significant correlation with birthweight and length, respectively (P < 0.01), although GH and insulin levels did not (P > 0.05). There was a significant correlation between IGF-I and IGFBP-3 levels (P < 0.01, r = 0.64), but IGF-I and IGFBP-3 levels showed no relationship with GH or insulin levels. Birthweight correlated significantly with prepartum maternal weight, maternal weight gain and maternal height (P < 0.05), but birth length correlated significantly only with maternal height (P < 0.05). Conclusions: Our results suggest that fetal growth depends on fetal levels of IGF-I and IGFBP-3 and maternal factors, not on insulin or GH.... (author abst.) |
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