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Accession number;00A0259392
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| Title;Expression of tumor necrosis factor-.ALPHA. protein in the myocardium in fatal myocarditis. |
| Author;
JIBIKI T
(Chiba Univ. School Of Medicine, Jpn)
TERAI M
(Chiba Univ. School Of Medicine, Jpn)
TATENO S
(Chiba Univ. School Of Medicine, Jpn)
TOYOZAKI T
(Chiba Univ. School Of Medicine, Jpn)
HORIE H
(Chiba Children's Hospital, Chiba, Jpn)
NAKAJIMA H
(Funabashi Municipal Medical Center, Jpn)
NIWA K
(Chiba Cardiovascular Center, Jpn)
NIIMI H
(Chiba Univ. School Of Medicine, Jpn)
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Journal Title;Pediatr Int
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Journal Code:Z0373B
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ISSN:1328-8067
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VOL.42;NO.1;PAGE.43-47(2000)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.16 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Background: Tumor necrosis factor (TNF)-.ALPHA. is the most studied cytokine in the failing human heart and in experimental murine myocarditis. We have investigated the expression of (TNF)-.ALPHA. in the myocardium in human myocarditis. Methods: We examined endomyocardial biopsy (n = 4) and autopsy (n = 5) tissues obtained from nine patients diagnosed with myocarditis by the Dallas criteria. Expression of (TNF)-.ALPHA. in the hearts was immunohistochemically studied using monoclonal antibodies against human (TNF)-.ALPHA.. Results: Tumor necrosis factor-.ALPHA. protein was expressed in the myocardium of six of the nine patients studied. Four of five fatal patients showed intense immunoreactivity for TNF-.ALPHA. compared with survivors. Furthermore, left ventricular systolic function was reduced in patients with TNF-.ALPHA.-positive hearts. Conclusions: These findings may support the suggestion that TNF-.ALPHA. plays an irnportant role in cardiac dysfunction and myocytic darnage in fatal human myocarditis. (author abst.) |
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