Delay of liver maturation as a cause of transient neonatal galactosemia.
|
Accession number;00A0259396
|
| Title;Delay of liver maturation as a cause of transient neonatal galactosemia. |
| Author;
ONO H
(Hiroshima Univ. School Of Medicine, Jpn)
MAWATARI H
(Hiroshima Univ. School Of Medicine, Jpn)
MIZOGUCHI N
(Hiroshima Univ. School Of Medicine, Jpn)
EGUCHI T
(Hiroshima Univ. School Of Medicine, Jpn)
SAKURA N
(Hiroshima Univ. School Of Medicine, Jpn)
HAMAKAWA M
(Hiroshima City Medical Assoc. Clinical Lab., Hiroshima, Jpn)
|
Journal Title;Pediatr Int
|
Journal Code:Z0373B
|
ISSN:1328-8067
|
|
VOL.42;NO.1;PAGE.61-63(2000)
|
| Figure&Table&Reference;TBL.3, REF.8 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Background: Because a large amount of serum .ALPHA.-fetoprotein (.ALPHA.-FP) is synthesized in the liver of the fetus or premature newborn, high concentrations or delayed degradation of serum .ALPHA.-FP during the neonatal period may refiect hepatic immaturity. Methods: In order to evaluate the relationship between transient neonatal galactosemia and delay of liver maturation, the concentration and half-life of serum .ALPHA.-FP during the neonatal period were measured in patients with transient galactosemia and in normal neonates. Results: No significant differences were observed in the serum concentration of .ALPHA.-FP between normal and galactosemic patients less than 1 month of age. However, the half-life of serum .ALPHA.-FP was significantly longer in galactosemic patients between 15 and 60 days of age compared with age-matched normal neonates. Conclusion: Based on these results, we hypothesize that delay of liver maturation during the neonatal period, especially during the first 2 months after birth, can be a cause of transient neonatal galactosemia. (author abst.) |
|
|
|
Related Articles;
|
|
|
