The influence of angiotensin-II on uteirne blood flow in pregnant rabbits.
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Accession number;00A0358505
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| Title;The influence of angiotensin-II on uteirne blood flow in pregnant rabbits. |
| Author;
NAKAOKA YUKIHARU
(Kinsyukai Hanwa Sumiyoshi Sogo Byoin)
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Journal Title;Advances in Obstetrics and Gynecology
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Journal Code:Z0452B
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ISSN:0370-8446
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VOL.52;NO.2;PAGE.132-138(2000)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.22 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Refractoriness to pressor substances, such as angiotensin-II(A-II), during pregnancy is well known. It is also recognized that A-II causes an increase in uterine blood flow in a pregnant dog. Nitric oxide appears to play an important role in regulating uterine blood flow. The purpose of this study was to clarify the influence of A-II on uterine blood flow during pregnancy, the effect of nitric oxide by the use of L-nitro-N-arginine (a nitric oxide synthase inhibitor), and the effect of prostaglandins by the use of ibuprofen (a cyclooxygenase inhibitor) on the changes in uterine blood flow by A-II. Pregnant rabbits under urethane anesthesia were instrumented to measure the mean arterial pressure and uterine blood flow by an electromagnetic flow meter. A-II was infused at a rate of 80ng/kg/min. through the femoral vein. The pregnant rabbits (gestational days: 17-22) were divided into 2 groups. In group I, after A-II infusion, L-nitro-N-arginine was administered at a rate of 75.MU.g/kg/min iv for 20 minutes. After a ten minutes cessation of the infusion of L-nitro-N-arginine, A-II was infused at the same rate. Then, after a L-arginine administration (100mg/kg), an A-II infusion was repeated at the same rate. In group II after an A-II infusion, ibuprofen was administered at a rate of 1mg/kg/min iv for 20 minutes. After a ten minutes cessation of the infusion of ibuprofen A-II was infused at the same rate. Then. L-nitro-N-arginine was administered at the same rate and an A-II infusion was repeated at the same rate. As a result, in group I, the mean blood pressure increased 19.8.+-.2.8% before L-nitro-N-arginine was administered, 24.3.+-.6.7% after, and 23.5.+-.6.5% after L-arginine was administered by A-II infusion. Uterine blood flow increased 40.7.+-.15.9% before L-nitro-N-arginine was administered, decreased 15.1.+-.5.3% after, and increased 15.5.+-.2.4% after a L-arginine administration by A-II infusion.... (author abst.) |
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