Domestic and foreign situation regarding changes in drug-resistant bacteria and the infections they cause.
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Accession number;00A0471423
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| Title;Domestic and foreign situation regarding changes in drug-resistant bacteria and the infections they cause. |
| Author;
KONNO MASATOSHI
(Teikyo Univ.)
ARAKAWA YOSHICHIKA
(National Inst. Infectious Diseases, JPN)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.48;NO.4;PAGE.251-277(2000)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.198 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In conducting studies titled "Studies on Evaluation of Drug-Resistant Bacteria Causing Hospital Infections and Measures to Counter Them" supported by a Grant-in Aid for Scientific Research from the Ministry of Health and Welfare for 1999 (Comprehensive Research Project for Drug Safety), we thought it necessary to clarify from what point of view to understand, and how to evaluate, the "Domestic and Foreign Situation Regarding Changes in Drug-Resistant Bacteria and The Infections They cause". Firstly, therefore, we went back to the days when antimicrobial chemotherapy originated and confirmed the basics of what meaning to seek in antimicrobial chemotherapy. Then, we stated the role that antimicrobial chemotherapy has played in the control of communicable infections in the context of infection control measures, such as vaccine therapy and the preparation of a good living environment. Second, we discussed the background of infections caused by sulfa-resistant Shigella, multidrug-resistant Shigella, multidrug-resistant staphylococci, multidrug-resistant gram-negative bacilli, Pseudomonas spp., MRSA, penicillin-resistant pneumococci, .BETA.-lactamase-nonproducing ampicillin-resistant Haemophilus infiuenzae, vancomycin-resistant enterococci, and mtiltidrug-resistant Mycobacterium tuberculosis all of which have emerged successively with the development of antimicrobial agents. Third, we addressed microbial resistance mechanisms faced by .BETA.-lactam antibiotics, aminoglycosides, macrolides, new quinolones, vancomycin, rifampicin, and antifungal drugs. Lastly, in view of the above-mentioned three problems, we referred to the ideal antimicrobial therapy as a medical treatment at present and in the future. (author abst.) |
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