Characterizaton of Hyperinsulinemic Recombinant Inbred(RI) Strains(SMXA-5 and SMXA-9) Derived from Normoinsulinemic SM/J and A/J Mice.
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Accession number;00A0507792
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| Title;Characterizaton of Hyperinsulinemic Recombinant Inbred(RI) Strains(SMXA-5 and SMXA-9) Derived from Normoinsulinemic SM/J and A/J Mice. |
| Author;
ANUNCIADO R V P
(Nagoya Univ., Nagoya, Jpn)
HORIO F
(Hamamatsu Univ. School Of Medicine, Hamamatsu, Jpn)
OHNO T
(Hamamatsu Univ. School Of Medicine, Hamamatsu, Jpn)
TANAKA S
(National Chubu Hospital, Aichi, Jpn)
NISHIMURA M
(Nagoya Univ. School Of Medicine, Nagoya)
NAMIKAWA T
(Nagoya Univ., Nagoya, Jpn)
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Journal Title;Exp Anim
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Journal Code:Z0755A
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ISSN:1341-1357
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VOL.49;NO.2;PAGE.83-90(2000)
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| Figure&Table&Reference;FIG.4, TBL.2, REF.21 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We discovered two mouse strains(SMXA-5 and SMXA-9) with hyperinsulinemia among the substrains and progenitor strains(SM/J and A/J) of the SMXA recombinant inbred(RI) strains, and characterized the two strains at 20 weeks of age. SMXA-5(mean.+-.S.E.M: 9.6.+-.1.7ng/ml) and SMXA-9(7.7.+-.1.3ng/ml) males had higher serum immunoreactive insulin levels than SM/J(1.4.+-.0.3ng/ml) A/J(1.1.+-.0.1ng/ml) males in the nonfasting condition. The hypoglycemic response to insulin at 30min after injection was significantly less in SMXA-5 males than in SM/J mice. Glucose tolerance test revealed that the incidnece of impaired glucose tolerant males was 58%(11/19) in SMXA-5 and 42%(10/24) in SMXA-9 strains, but none in SM/J and A/J strains. SMXA-5(209.+-.29 mg/dl) and SMXA-9(235.+-.31mg/dl) had higher serum triglyceride levels than SM/J(126.+-.14mg/dl) and A/J(89.+-.5 mg/dl) males in the nonfasting condition. Histologic examination revealed enlarged islets in the pancreas of hyperinsulinemic SMXA-5 male mice. Moreover, SMXA-5 and SMXA-9 mice exhibited mild obesity. SMXA-5 and SMXA-9 males were therefore characterized by hyperinsulinemia, impaired glucose tolerance, hypertriglyceridemia and mild obesity which resembled some of the phenotypes of human Syndrome X, although both progenitor strains were normal so far as we examined. Since the RI strains are a powerful tool to facilitate polygenic-trait analysis, SMXA-5 and SMXA-9 mice will be useful materials to investigate the genetic basis of complex diseases, and are possible new metabolic models in relation to hyperinsulinemia. (author abst.) |
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