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Accession number;00A0557811
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| Title;The basic study of HIMAC-hyperthermia treatment. |
| Author;
ONISHI TAKEO
(Nara Med. Univ.)
ONISHI KEN
(Nara Med. Univ.)
TAKAHASHI AKIHISA
(Nara Med. Univ.)
TAMAMOTO TETSURO
(Nara Med. Univ.)
FURUSAWA YOSHIYA
(National Inst. of Radiological Sciences)
WANG X
(Nara Med. Univ.)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.64-65(1999)
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| Figure&Table&Reference;FIG.5 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In order to confirm the dependence on p53 status of the hyperthermic enhancement of radiation cytotoxicity, we used A-172 cells, carrying wild-type p53, transfectants with pCMV-Neo-Bam control vector (A-172/neo cells) or mutant p53Trp248-expression vector (A-172/mp53 cells). The enhancement of combined treatment of radiation and hyperthermia in cytotoxicity was observed only in A-172/neo. The thermal enhancement of radiation-induced cell killing was LET-dependent for the A-172/neo cells, but this was not clearly demonstrated in the A-172/mp53 cells. We have obtained confirmatory evidence that the hyperthermic enhancement of cell killing is p53-dependent. (author abst.) |
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