Characterization of cellular response to radiation (12C ion beam). Modification of Killing Effects of Carbon Ions.
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Accession number;00A0557814
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| Title;Characterization of cellular response to radiation (12C ion beam). Modification of Killing Effects of Carbon Ions. |
| Author;
SUZUKI NORIO
(Univ. of Tokyo, Fac. of Med.)
SAKAI KAZUO
(Univ. of Tokyo, Fac. of Med.)
HIRANO KAZUYA
(Univ. of Tokyo, Fac. of Med.)
FURUSAWA YOSHIYA
(National Inst. of Radiological Sciences)
ANDO KOICHI
(National Inst. of Radiological Sciences)
KANG Y
(National Inst. of Radiological Sciences)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.70-71(1999)
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| Figure&Table&Reference;FIG.3 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Killing effects of carbon ions were compared to that of X-rays in 7 cultured mammalian cell lines (human glioma A172, A7, T98G, U87MG; human leukemic MOLT-4, U937; Chinese hamster V79). RBE values, estimated at 10% survival level, were 1.8 to 2.4. The modification of killing effect by treatment with hyperthermia or zinc ions were studied in V79, one of the most resistant cell line to both X-rays and carbon ions. Hyperthermic treatment (44.DEG.C., 20 min) given prior to irradiation enhanced the killing effect of both X-rays and carbon ions. The thermal enhancement ratio was, however, reduced in carbon irradiated cells: 1.3 at 10% survival level for carbon ions and 2.5 for X-rrays. Radiosensitizing effect of zinc ions was also reduced in cells irradiated with carbon ions. (author abst.) |
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