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Evaluation of Early and Late Skin Damage after Heavy-Ion Radiation.

Accession number;00A0557816

Title;Evaluation of Early and Late Skin Damage after Heavy-Ion Radiation.

Author; MATSUSHITA SATORU (National Inst. of Radiological Sciences) KAWANO AKIHIRO (National Inst. of Radiological Sciences) ANDO KOICHI (National Inst. of Radiological Sciences) KOIKE SACHIKO (National Inst. of Radiological Sciences) KANAI TATSUAKI (National Inst. of Radiological Sciences) SATO YOSHIKO (National Inst. of Radiological Sciences) IRITANI RIICHIRO (Saiensusabisu) CHIN G (National Inst. of Radiological Sciences)

Journal Title;NIRS-M (Natl Inst Radiol Sci)

Journal Code:Z0881A

ISSN:

VOL.;NO.133;PAGE.74-75(1999)

Figure&Table&Reference;REF.1

Pub. Country;Japan

Language;Japanese

Abstract;Normal tissue damage is one of the most dose-limiting factors in clinical rediotherapy. Little is known yet concerning such damage induced by heavy-ion radiation. This study was conducted to evaluate the late radiation damage of the normal tissues after irradiation with heavy ion beams. The right hind legs of the mice were irradiated by single doses of 290 MeV/u carbon-12 with a 6cm width SOBP accelerated by HIMAC. Skin shrinkage, thickness of the skin tissues, posterior knee angle between the femur and tibia were measured one year after the irradiation at 15, 60 and 100keV/.MU.m at the doses between 5 to 40Gy. RBEs were obtained from the dose-response curves of these endpoints, and compared with those of fast nertrons. 1. RBEs of skin shrinkage at 35% level: neutrons=2.3, carbon (C-)15keV/.MU.m=1.6, C-60keV/.MU.m=2.0, C-100keV/.MU.m=1.9. 2. RBEs of knee angle at 100 degree level: neutrons=1.7, C-15keV/.MU.m=0.9, C-60keV/.MU.m=1.8. 3. RBEs of thickness of the skin tissue at 200.MU.m level: neutrons=2.3, C-15keV/.MU.m=1.9, C-60keV/.MU.m=2.3. (author abst.)

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