Effects of Heavy Ion Irradiation on Bone Metabolism and the Related organs in Rats.
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Accession number;00A0557818
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| Title;Effects of Heavy Ion Irradiation on Bone Metabolism and the Related organs in Rats. |
| Author;
FUKUDA SHUN
(National Inst. of Radiological Sciences)
IIDA HARUMI
(National Inst. of Radiological Sciences)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.78-79(1999)
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| Figure&Table&Reference;FIG.2, REF.3 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The effects of heavy ion radiation on bone and calcium metabolism were examined 2 weeks after irradiation, doses of 1.25-5.0 Gy, in 3-month-old male rats. The trabecular bone mineral density in the femoral and tibial metaphyses decreased significantly, while the cortical bone mineral density in the diaphyes rather tended to increase. The changes in histomorphometric values were observed: increases in trabecular separation, osteoid volume, and eroded depth. The negative calcium balance was also observed by decline in calcium intestinal absorption and increase in calcium excretion in urine. The decreases in parathyroid hormone and ostocalcin, and in skeletal muscle weight, and increase in adrenal gland weight were observed. The results indicated that, in the early period after irradiation, particularly in the 1.25-2.5 Gy groups, the bone loss by the decrease in bone mineral density and inhibition of calcification and acceleration in bone resorption had started, and enlarged by functional damages in parathyroid, intestine, kidney, including while atrophy of cortical bone occurred suggesting increase in bone mineral density and bone strength. (author abst.) |
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