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RBE of heavy ions(carbon, proton) for chronogenecities of growing cartilage cells and for acute cell death of pancreatic islet cells.

Accession number;00A0557819

Title;RBE of heavy ions(carbon, proton) for chronogenecities of growing cartilage cells and for acute cell death of pancreatic islet cells.

Author; TSUBOUCHI SUSUMU (Suzuka Univ. Medical Sci.) FUKUTSU KUMIKO (National Inst. of Radiological Sciences) ITSUKAICHI HIROMI (National Inst. of Radiological Sciences) MURAKAMI MASAHIRO (National Inst. of Radiological Sciences) FURUSAWA YOSHIYA (National Inst. of Radiological Sciences) MATSUSHITA SATORU (National Inst. of Radiological Sciences) OHARA HIROSHI (Okayama Univ.) YATAGAI FUMIO (Inst. of Physical and Chemical Res.) KANO EIICHI (Fukui Med. Sch.)

Journal Title;NIRS-M (Natl Inst Radiol Sci)

Journal Code:Z0881A

ISSN:

VOL.;NO.133;PAGE.80-81(1999)

Figure&Table&Reference;

Pub. Country;Japan

Language;Japanese

Abstract;This study was designed to obtain RBE of heavy ions(carbon, neutron, or proton) for chronogenecities of growing cartilage cells and for acute cell death of pancreatic islet cells. Experiments of growing ICR/JCL mouse tail bone cartilage for dose response curve of chronogenic cells indicated that D0 of the cells with 290 Mev carbon was roughly same as 200 KeV X-ray, and 30 MeV neutron. The curve shifted toward low dose in the sequence of carbon, neutron and x-ray. Therefore obtained RBEs of neutron, and 20 and 60 KeV carbons at one cell survival level per the tissue plate were 1.3, 1.4, and 1.8 respectively. Also dose response relations in acute cell death of pancreatic islet studied histologically after whole body irradiation of golden hamster with X-ray, proton and carbon beams indiated that Dos of the each three beams were 58 Gy, 51 Gy, and 70 Gy, respectively. Estimated RBEs of proton and carbon beams from Do values were 1.1 and 0.83. Low RBE of carbon beams with repeated experments were consisitent with the results of oocytesandlymphocytes. (author abst.)

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