Studies on radiation induced brain dysfunction.
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Accession number;00A0557820
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| Title;Studies on radiation induced brain dysfunction. |
| Author;
YAMAGUCHI MASATOSHI
(Fukuoka Univ., Fac. of Pharm. Sci.)
TAKAI NOBUHIKO
(Fukuoka Univ., Fac. of Pharm. Sci.)
KOBAYASHI KAORU
(Osaka Univ., Med. Sch.)
HOSOI RIE
(Osaka Univ., Med. Sch.)
ISHIKAWA MEGUMI
(Osaka Univ., Med. Sch.)
INOUE OSAMU
(Osaka Univ., Med. Sch.)
NOJIMA KUMIKO
(National Inst. of Radiological Sciences)
ANDO KOICHI
(National Inst. of Radiological Sciences)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.82-83(1999)
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| Figure&Table&Reference;FIG.1, TBL.1 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Male C3H mice (8 w.o.) were anaesthetized with pentobarbital, and the head of the animal were fixed and irradiated with 290 MeV of 12C beam (3, 10, 30Gy). At 3-4 hrs after the irradiation, mice were intravenously injected with either 3H-SCH23390, 3H-N-methylspiperone(NMSP) or 3H-QNB, and decapitated 60 min after the tracer injection. The radioactivity concentrations in cerebral cortex, striatum and cerebellum were measured and expressed a percent injected dose per gram tissue (%dose/g). For the quantitative analysis of in vivo binding of dopamine D1 and D2 receptors, the cerebellum was used as a reference region, and the ratios of radioactivity concentrations in the striatum and cerebral cortex to those in the cerebellum were calculated. No significant changes were observed in dopamine receptor binding as well as 3H-QNB binding in vivo by heavy ion irradiation. The results were much different from previous observation induced by proton beam irradiation. One possible reason seemed to be due to the effect of pentobarbital anesthesia. As pentobarbital has reported to induce global changes in receptor binding in vivo, it seems to be important to avoid the effect of pentobarbital on the receptor binding study in vivo. (author abst.) |
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