Radiation effects of heavy ion particles on bone metabolism.
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Accession number;00A0557821
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| Title;Radiation effects of heavy ion particles on bone metabolism. |
| Author;
NAKAMURA MASAYASU
(Hokkaido Univ., Sch. of Dent.)
SAWAJIRI MASAHIKO
(Hokkaido Univ., Sch. of Dent.)
KOGO TAKAO
(Hokkaido Univ., Sch. of Dent.)
IIZUKA TADASHI
(Hokkaido Univ., Sch. of Dent.)
MIZOE JUN'ETSU
(National Inst. of Radiological Sciences)
ANDO KOICHI
(National Inst. of Radiological Sciences)
FUKUDA SHUN
(National Inst. of Radiological Sciences)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.84-85(1999)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In 1998, we performed experiments on single-dose irradiation to rat bone. These experiments were conducted to investigate the effects of single carbon-12 beam and gamma-ray radiation on bone damage. Three-week-old male rats were divided into three groups: group A was exposed to heavy-ion irradiation, group B was exposed to gamma-ray irradiation and group C (control) was not exposed to any irradiation. The legs of Wister rats were irradiated by single doses of 290 MeV/u carbon-12 with a 6-cm-wide Spread-Out-Bragg-Peak (SOBP). LET of 40keV/.MU.m of carbon-12 beams was used and was applied at doses of 15, 22.5 and 30Gy to the bone. Gamma rays were also applied at same dose to the legs of the rats. The rats were sacrificed at 1, 2, 3, 5, and 7 days, and 4, 12, 18, and 24 weeks after irradiation and bone reaction after irradiation was observed. Histological sections of the legs were prepared to evaluate bone volume and number of osteoclasts. We fixed the endpoint to obtain RBE of the bone as a decrease or increase in bone volume and osteoclast number. Morphological analysis revealed that change occurred in the secondary spongiosa in the proximal metaphysis: a simple increase in bone volume with a loss of osteocasts in the early pried. The number of osteoclasts rapidly decreased three days after heavy-ion irradiation, which was about two days shorter than the rapid decrease following gamma ray irradiation. Bone volume in the control group was almost regularized during our investigation, whereas in the heavy-ion irradiated group, bone volume increased until the fourth week after irradiation and the decreased. This response took three weeks longer than the response in the gamma-ray group.... (author abst.) |
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