Science Links Japan | Response of Mouse Intestine to Carbon-12 Beams in Relation to Dose Fraction and Effects of Steroids on Radiation-Induced Intestinal Damages.

Response of Mouse Intestine to Carbon-12 Beams in Relation to Dose Fraction and Effects of Steroids on Radiation-Induced Intestinal Damages.

Accession number;00A0557822

Title;Response of Mouse Intestine to Carbon-12 Beams in Relation to Dose Fraction and Effects of Steroids on Radiation-Induced Intestinal Damages.

Author; YAMADA SHIGERU (National Inst. of Radiological Sciences) ANDO KOICHI (National Inst. of Radiological Sciences) KOIKE SACHIKO (National Inst. of Radiological Sciences) NOJIMA KUMIE (National Inst. of Radiological Sciences) MAJIMA HIDEYUKI (National Inst. of Radiological Sciences) TSUJII HIROHIKO (National Inst. of Radiological Sciences)

Journal Title;NIRS-M (Natl Inst Radiol Sci)

Journal Code:Z0881A

ISSN:

VOL.;NO.133;PAGE.86-87(1999)

Figure&Table&Reference;FIG.3

Pub. Country;Japan

Language;Japanese

Abstract;Dose-fractionation regimes for HIMAC therapy of tumors are ultimately determined by the responses of normal tissues of patients. The survival of mouse jejunal crypt cells after multiple doses of carbon beams has been measured with microcolony technique. Effects of fractionated irradiation on jejunal crypts were studied by 3 fractions with 4-hours inter-fractional interval. Fractionated irradiation elevated survival of crypt cells. Steroid are currently used to treat radiation enterocolitis in humans. Intraperitoneal steroids or saline were given one hour before irradiation. Steroid protected jejunal crypt cells against damages by carbon beams. (author abst.)

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