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Accession number;00A0557823
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| Title;Histological and cellular studies of central nervous system after heavy particle irradiation. |
| Author;
NOJIMA KUMIE
(National Inst. of Radiological Sciences)
FUJIWARA HIROMITSU
(National Inst. of Radiological Sciences)
SHIMADA YOSHIYA
(National Inst. of Radiological Sciences)
KAKINUMA SHIZUKO
(National Inst. of Radiological Sciences)
ANDO SOICHIRO
(National Inst. of Radiological Sciences)
KOIKE SACHIKO
(National Inst. of Radiological Sciences)
ANDO KOICHI
(National Inst. of Radiological Sciences)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.88-89(1999)
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| Figure&Table&Reference;FIG.3, REF.4 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We investigated biological effects of heavy particle irradiation on central nervous system using histological and cellular methods. 1) Brain cells of new-born mice were primary-cultured, and then irradiated with X-rays and carbon ions. Cell kinetics studies using cell surface antibody and flowcytometry showed that microglia and astrocyte were sensitive and resistant, respectively, to irradiation with 2-16Gy of either radiation qualities. The sensitive cells were microglia and resistant cells were astrocyte. 2) We measured behavior and circadian rhythm of whole-brain irradiated mice. 3) Rats were irradiated to the spinal cord with various doses of carbon beam, the ED50 for paralysis was 15.5Gy. (author abst.) |
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