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Accession number;00A0557824
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| Title;Comparison of effects between carbon and neon beams on leukemogenesis in mice. |
| Author;
KAWASE YOSHIKO
(National Inst. of Radiological Sciences)
WATANABE TOSHIAKI
(Yamagata Univ., Sch. of Med.)
AKASHI MAKOTO
(National Inst. of Radiological Sciences)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.90-92(1999)
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| Figure&Table&Reference;FIG.1, REF.4 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Previously, we studied effects of x-rays and heavy ion particle exposure of carbon 12 beam on induction of myeloid leukemias in RFM/MsNrs male mice. Our results show that whole body exposure to heavy ion particle carbon-12 induces myeloid leukemias as well as x-rays. In this study, we compared effects of either carbon-12 or neon irradiation on the quantitative change of total either leukocytes, neutrophils, or platelets of peripheral blood in these mice. Mice were subjected to a single exposure (1-3Gy) of whole body either carbon-12 or neon irradiation. A similar rapid reduction of the counts of leukocytes and neutrophils was observed in both groups following irradiation; nadir in leukocytes was on day 2 without 3Gy group in neon beam. The number of leukocytes in mice irradiated with a neon beam was significantly lower than that in mice irradiated with a carbon beam. The counts of platelets were rapidly decreased and the nadir in both groups was observed on day 7. Although irradiation with a neon beam induced a severe suppression of the counts of platelets as compared to carbon beam, the complete recovery in the count of platelets was observed on irradiation with a neon beam during the observation period. Our results suggest that irradiation with a neon beam induces a rapid reduction of leukocytes and a strong suppression of platelets counts as compared to a carbon beam irradiation. (author abst.) |
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