Detection of DNA damage by heavy-ion beam in mouse multiple organs.
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Accession number;00A0557825
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| Title;Detection of DNA damage by heavy-ion beam in mouse multiple organs. |
| Author;
OTA SHIGENORI
(Hachinohe Natl. Coll. of Technol.)
WADA SEIICHI
(Kitasato Univ., Sch. of Vet. Med. and Anim. Sci.)
UENO SHUNJI
(Kitasato Univ., Sch. of Vet. Med. and Anim. Sci.)
SUSA NOBUYUKI
(Kitasato Univ., Sch. of Vet. Med. and Anim. Sci.)
NATSUHORI MASAHIRO
(Kitasato Univ., Sch. of Vet. Med. and Anim. Sci.)
ITO NOBUHIKO
(Kitasato Univ., Sch. of Vet. Med. and Anim. Sci.)
FURUSAWA YOSHIYA
(National Inst. of Radiological Sciences)
NISHIMURA YOSHIKAZU
(National Inst. of Radiological Sciences)
SASAKI YU
(Hachinohe Natl. Coll. of Technol.)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.93-94(1999)
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| Figure&Table&Reference;FIG.1 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The aim of the present study was to investigate the effects of carbon-ions (HIMAC) irradiation on the production of DNA damage in mouse 9 organs. Group of four male C3H mice was irradiated to carbon-ions at 20 Gy. Nine organs (stomach, colon, liver, kidney, urinary bladder, lung, brain, thymus, and bone marrow) were taken 0, 9, 24 hr after the irradiation and DNA damage was detected by the comet assay. DNA double strand breaks (DSB) and single strand breaks (SSB) were detected in all the organs studied. DSB in all the organs peaked at 0 h and decreased. DSB in the liver, kidney, lung, brain, thymus, and bone marrow peaked at 0 h and decreased to return to almost the control level at 24 h. In the stomach, on the contrary, DSB peaked at 9 h and returned to almost control level at 24 h. These results suggest that the kinetics of DNA break induction is different for different organs. (author abst.) |
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