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Accession number;00A0557827
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| Title;Induction of Asymmetrical Type of Chromosome Aberrations in Human Lymphocytes by Heavy Ions at NIRS-HIMAC. |
| Author;
OHARA HIROSHI
(Okayama Univ., Fac. of Sci.)
OKAZAKI NORIE
(Okayama Univ., Fac. of Sci.)
MONOBE MANAMI
(Okayama Univ., Fac. of Sci.)
FURUSAWA YOSHIYA
(National Inst. of Radiological Sciences)
MINAMIHISAMATSU MASAKO
(National Inst. of Radiological Sciences)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.97-98(1999)
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| Figure&Table&Reference;REF.2 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Induction of asymmetrical type of chromosome aberrations were investigated by irradiating human lymphocytes with 5 different qualities of ion beams at NIRS-HIMAC. The radiations used for the present study were the carbons (290n MeV/n) with 3 different LETs of 40, 80 and 100 KeV/.MU.m, the neons (400Mev/n) with 2 different LETs of 80 and 100 KeV/.MU.m, and the X-rays with 100 and 200 kVp as the references. The irradiated bloods were cultured with PHA for the mitoses of lymphocytes in RPMI 1640 medium for about 53-74 hrs at 37.DEG.C.. Asymmetric types of aberrations such like dicentrics, rings and isochromatid type of fragments were mainly observed. The main results obtained were; 1) the dose responses for the induction of aberrations with heavy ion beams were linear and the production of the fragments were superior to those of dicentrics and rimgs, 2) the RBEs in terms of slope change of the dose responses were LET-dependent to give a local peak in the range 80-100 KeV/.MU.m, and 3) the heavy ions was found to produce an exceeding amount of the fragments, suggesting an increase of terminal deletions and an inhibition of repair of chromosome breaks. (author abst.) |
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