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Accession number;00A0557828
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| Title;Effects of heavy ions on the proliferation and differentiation of neural stem cells in postnatal mice. |
| Author;
FUSHIKI SHINJI
(Kyoto Prefect. Univ. of Med.)
KINOSHITA CHIKAKO
(Kyoto Prefect. Univ. of Med.)
YAOI TAKESHI
(Kyoto Prefect. Univ. of Med.)
NOJIMA KUMIE
(National Inst. of Radiological Sciences)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.99-101(1999)
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| Figure&Table&Reference;FIG.2 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To elucidate the effects of heavy ions on the population of neural stem cells present in postnatal mouse brains from the viewpoint of cell death, we analyzed morphologically and immunochemically the following three regions, i.e., rostral migratory stream, hippocampus and cerebellum. Apoptotic cells (as evaluated by nuclear fragmentation) appeared 1 hours after exposure to heavy ion particles and the ratio of apoptotic cells reached a peak value at 12 hours after the exposure. The number of cells showing morphological features of apoptosis increased with increasing doses of radiation, ranging from 0.25 Gy to 2.0 Gy, in all the three regions examined. Immunoblot analyses for Bad protein revealed an increased density of the band at the dose of 0.25 Gy and higher. Our study indicates that cell death appears among neural stem cell population of postnatal mice shortly after low-dose exposure to heavy ion beams and suggests that up-regulation of Bad proteins is involved in the underlying molecular mechanisms. (author abst.) |
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