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Accession number;00A0557796
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| Title;The limited operation combined with heavy ion particle radiotherapy for breast cancer. |
| Author;
MATSUZAKI H
(Chiba Univ.)
MIYAMOTO T
(National Inst. of Radiological Sciences)
MIYAZAWA Y
(Chiba Univ.)
ISINO K
(Chiba Univ.)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.13-23(1999)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.30 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Background: Radioresistance of the extensive intraductal component (EIC) is a major limiting factor in breast conserving therapy (BCT). The purpose of the present experiment was to elucidate the biological effects of a carbon beam on human breast cancer cell lines to evaluate its clinical benefits in BCT. Methods: Human breast cancer cell lines grown in culture and inoculated in nude mice were subjected to X-ray (200 kV) and heavy ion beam (290 MeV/u carbon beam) irradiation. At the level of D10 (10% survival dose) on the dose-survival curve, the relative biological effectiveness (RBE) of the carbon beam to X-ray irradiation was determined. By using the colony forming assay of the three cultured cell lines (YMB-I, OUUB-M, CRL-1500), the survival curves at the LET of 80 KeV/.MU.m were obtained. An established cancer on nude mice was exposed to single-dose and triple-fractionated irradiations at the LET of 50 KeV/.MU.m, and the growth of tumors at various doses was observed and the survival curves were determined by using the tumor regrowth assay. Results: The RBE of carbon beam on each cell line ranged from 2.17 to 2.89 (2.59 0.37). That of the tumor on nude mice was 1.53 and 2.00 on exposure to single-dose and fractionated irradiation, respectively. Conclusions: The human breast cancer cell lines showed high intrinsic sensitivity to a carbon beam and its tumor effects were enhanced by fractinated irradiation. It is worthy that a carbon beam is applied to use for clinical trials on BCT. (author abst.) |
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