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Accession number;00A0557802
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| Title;Chromosomal Aberrations Detected by PCC+FISH in Lymphocytes from Cancer Patients Given X-rays or Carbon Beams. |
| Author;
YAMADA SHIGERU
(National Inst. of Radiological Sciences)
DURANTE M
(National Inst. of Radiological Sciences)
KAWATA TETSUYA
(National Inst. of Radiological Sciences)
NAKANO TAKASHI
(National Inst. of Radiological Sciences)
ANDO KOICHI
(National Inst. of Radiological Sciences)
FURUSAWA YOSHIYA
(National Inst. of Radiological Sciences)
MAJIMA HIDEYUKI
(National Inst. of Radiological Sciences)
TSUJII HIROHIKO
(National Inst. of Radiological Sciences)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.38-39(1999)
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| Figure&Table&Reference;FIG.3, REF.1 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We report mesurments of chromosomal aberrations in peripheral blood lymphocytes from patients undergoing treatment with X-rays or carbon ions. The novel technique of interphase chromosome painting. A to induce premature chromosome condensation. Spreads were hybridized in situ with whole-chromosome DNA probes specific for human chromosomes 2 and 4. Fraction of aberrant lymphocytes was measured as a function of the dose to the tumor. A clear dependence upon radiation field size was found in patients treated with X-ray. Aberrations increase as a function of the tumor dose, and at high doses they reach a saturation level, which is lower for patients treated with C-ions than X-rays. The results demonstrate that C-ions induce a lower level of cytogenetic damage in circulating lymphocytes than X-rays. (author abst.) |
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