Distributions of HL91, deoxyglucose, and GLUT1 in tumor.
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Accession number;00A0557805
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| Title;Distributions of HL91, deoxyglucose, and GLUT1 in tumor. |
| Author;
NISHIMURA TSUNEHIKO
(Osaka Univ., Med. Sch.)
TATSUMI MITSURO
(Osaka Univ., Med. Sch.)
ABURAYA KENJI
(Osaka Univ., Med. Sch.)
NAKANO TAKAYUKI
(Osaka Univ., Med. Sch.)
INOUE OSAMU
(Osaka Univ., Med. Sch.)
YOSHIKAWA KYOSAN
(National Inst. of Radiological Sciences)
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Journal Title;NIRS-M (Natl Inst Radiol Sci)
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Journal Code:Z0881A
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ISSN:
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VOL.;NO.133;PAGE.49-50(1999)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Technetium-99m-HL91 (HL91) is a potential agent for imaging hypoxic tissue in vivo. To elucidate the relationship between hypoxia and blood flow in a tumor, dual-tracer autoradiography with HL91 and C-14-iodoantipyrine (IAP) was performed in a tumor-bearing rat model. The distribution of each tracer was analyzed visually and semiquantitatively. In the tumors with central necrotic areas, HL91 uptake was marked around the necrotic areas. IAP uptake was marked at the periphery of the tumors, around the areas of marked HL91 uptake. Normalized HL91 uptake (%HL91) was highest in the low-normalized IAP uptake (%IAP) fraction in the non-necrotic areas. There was a weak negative correlation between %HL91 and %IAP in the non-necrotic areas (r=-0.322, p<0.0001). In tumors with few or no necrotic areas, HL91 uptake was observed heterogeneously throughout the tumors, while IAP uptake was predominant at the periphery of the tumors. %HL91 was higher in the inner two-thirds of the tumor than in the outer third. There was also a weak negative correlation between %HL91 and %IAP (r=-0.354, p<0.0001). This study confirmed that high HL91 uptake is related to low blood flow. The marked HL91 uptake around the necrotic region suggests the presence of chronic hypoxia in a tumor. (author abst.) |
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