Regulation of CD31 expression and interleukin-4 production by human cord blood CD4+ T cells with interleukin-4 and interleukin-7.
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Accession number;00A0435928
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| Title;Regulation of CD31 expression and interleukin-4 production by human cord blood CD4+ T cells with interleukin-4 and interleukin-7. |
| Author;
KATAMURA K
(Kyoto Univ., Kyoto, Jpn)
FUKUI T
(Kyoto Univ., Kyoto, Jpn)
KIYOMASU T
(Kyoto Univ., Kyoto, Jpn)
OHMURA K
(Kyoto Univ., Kyoto, Jpn)
IIO J
(Kyoto Univ., Kyoto, Jpn)
UENO H
(Kyoto Univ., Kyoto, Jpn)
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Journal Title;Pediatr Int
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Journal Code:Z0373B
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ISSN:1328-8067
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VOL.42;NO.2;PAGE.126-133(2000)
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| Figure&Table&Reference;FIG.4, TBL.2, REF.30 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Background: T helper 2 cell type cytokines, such as interleukin (IL)-4 and IL-5, play pivotal roles in the development of allergic diseases. However, the mechanism by which naive CD4+ T cells acquire the ability to produce these cytokines remains unclear. Recently, it was reported that IL-7 induces the ability to produce IL-4 as well as interferon (IFN)-.GAMMA. and IL-5 in naive CD4+ T cells without TCR stimulation. To further analyze the mechanism of acquiring IL-4-producing ability by naive CD4+ T cells, the effects of IL-7 on human cord blood CD4+ T cells were compared with those of IL-4, which induced the ability to produce IFN-.GAMMA. but not IL-4. Results: Interleukin-7 preserved the population of CD4+ CD31- T cells in cord blood and induced their IL-4-producing ability without T cell receptor (TCR) stimulation, while IL-4 induced CD31 on CD31- T cells and could not induce their IL-4-producing ability. Both the CD31-inducing effect and the inhibitory priming effect for IL-4-production by IL-4 were also observed after cord blood CD4+ T cells had been primed with IL-7 and acquired the IL-4-producing ability. Conclusions: Interleukin-7 induced the IL-4-producing ability in naive CD4+ CD31- T cells without TCR stimulation, suggesting that the signal transduction via CD31 may have an inhibitory effect on the acquisition of the IL-4-producing ability by cord blood CD4+ T cells in the absence of TCR stimulation. (author abst.) |
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