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Accession number;00A0435930
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| Title;Anti-interleukin-8 auto-antibodies in cerebrospinal fluid of children with purulent meningitis. |
| Author;
TAKASAKI J
(Saitama Medical School, Saitama, Jpn)
OGAWA Y
(Saitama Medical School, Saitama, Jpn)
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Journal Title;Pediatr Int
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Journal Code:Z0373B
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ISSN:1328-8067
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VOL.42;NO.2;PAGE.139-142(2000)
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| Figure&Table&Reference;FIG.3, REF.8 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Background: Cerebrospinal fluid (CSF) of patients with purulent meningitis contains a high concentration of interleukin (IL)-8. Recently, the presence of anti-IL-8 auto-antibodies was noted in blood and alveolar fluid. Therefore, measurement of the concentration of anti-IL-8 auto-antibodies was attempted in CSF of children with and without meningitis. Methods and Results: We measured the concentration of anti-IL-8 auto-antibodies in CSF of children with purulent or aseptic meningitis and those without meningitis. The CSF obtained on admission showed a significantly higher concentration of anti-IL-8 IgG and IgM auto-antibodies in children with purulent meningitis, compared with those with aseptic meningitis or without meningitis. Among the three groups of children, the concentration of IL-8 was also significantly higher in CSF of children with purulent meningitis. Conclusion: Because the anti-IL-8 IgG auto-antibody binds to IL-8 and inhibits IL-8 interaction with specific receptors on neutrophils, the presence of anti-IL-8 auto-antibodies seems to provide a mechanism that limits the bioavailability of free IL-8 in CSF. (author abst.) |
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