Effects of growth hormone replacement therapy on lipids, lipoproteins and apolipoproteins. Is the increased apolipoprotein A-1/B ratio the only benefit?
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Accession number;00A0435932
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| Title;Effects of growth hormone replacement therapy on lipids, lipoproteins and apolipoproteins. Is the increased apolipoprotein A-1/B ratio the only benefit? |
| Author;
YILDIZ M
(Ssk Goeztepe Education Hospital, Istanbul, Tur)
ARSLANOGLU I
(Ssk Goeztepe Education Hospital, Istanbul, Tur)
YILDIZ N
(Ssk Goeztepe Education Hospital, Istanbul, Tur)
NARTOP F
(Ssk Goeztepe Education Hospital, Istanbul, Tur)
ISIK K
(Ssk Goeztepe Education Hospital, Istanbul, Tur)
ISGUVEN P
(Ssk Goeztepe Education Hospital, Istanbul, Tur)
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Journal Title;Pediatr Int
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Journal Code:Z0373B
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ISSN:1328-8067
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VOL.42;NO.2;PAGE.151-154(2000)
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| Figure&Table&Reference;TBL.2, REF.20 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Background: The aim of the present study was to investigate the controversial role of growth hormone (GH) therapy in lipid regulation. Methods: We studied serum levels of cholesterol and subgroups, triglyceride and apolipoprotein A-1 and B in 41 GH-deficient children (with subgroups of untreated and short- and long-term treated subjects) and 20 healthy controls. Results: Cholesterol and low-density lipoprotein cholesterol levels (in mmol/L) were found to be 4.92.+-.1.34 and 3.02.+-.1.58 in untreated, 4.15.+-.0.72 and 2.46.+-.0.65 in short-term (3 month) treated, 4.93.+-.1.39 and 3.15.+-.1.38 in long-term (>1 year) treated and 4.11.+-.0.5 and 2.0.+-.0.74 in control subjects, respectively. The apolipoprotein A-1:B ratio was 1.98.+-.0.5 in long-term treated and 1.6.+-.0.6 in control subjects. Conclusions: The improvement of lipid composition with short-term GH therapy is temporary, but the increase in apo A-1:B is not and seems to be the particular benefit of this therapy. (author abst.) |
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