Detection of IgE Antibodies Specific for Malassezia Species in Sera of the Patients with Atopic Dermatitis.
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Accession number;00A0533967
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| Title;Detection of IgE Antibodies Specific for Malassezia Species in Sera of the Patients with Atopic Dermatitis. |
| Author;
KOYAMA TOMOKI
(Nagoya Univ., Sch. of Med.)
KAMBE TOSHIO
(Nagoya Univ., Res. Inst. for Dis. and Mech. and Control)
ISHIGURO AYAKO
(Nagoya Univ., Sch. of Med.)
KIKUCHI AKIHIKO
(Nagoya Univ., Res. Inst. for Dis. and Mech. and Control)
TOMITA YASUSHI
(Nagoya Univ., Sch. of Med.)
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Journal Title;Skin Research
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Journal Code:Z0014B
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ISSN:0018-1390
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VOL.42;NO.1;PAGE.18-23(2000)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.19 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In order to consider the relation between atopic dermatitis (AD) and Malassezia, we examined the existence of IgE antibodies specific for Malassezia species in sera of 42 AD patients (24 males and 18 females) by Western blot. In either male and female, it was noted that positive rate of IgE antibodies to M. globosa was the highest (60% of the patients), and next, to M. sympodialis (52% of the patients). We found that there was significant correlation between the total IgE, the UA values of CAP-RAST and the total intensities of Western blot, respectively ; much more dominant correlation (r = 0.906) with the UA values of CAP-RAST and the total intensities of M. symopodialis, in particular. Therefore, these suggest that, in Malassezia species, M. globosa is the most principal as a mal-factor of AD and that CAP-RAST antigen can be attributed to M. sympodialis. (author abst.) |
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