Current Topics of Allergic Diseases. Staphylococcus aureus and Atopic Dermatitis.

Accession number;00A0456085
Title;Current Topics of Allergic Diseases. Staphylococcus aureus and Atopic Dermatitis.
Author; NOMURA ICHIRO (National Children's Hospital) AKASAWA AKIRA (National Children's Hospital)
Journal Title;Japanese Journal of National Medical Services
Journal Code:F0707A
ISSN:0021-1699
VOL.54;NO.2;PAGE.62-66(2000)
Figure&Table&Reference;FIG.2, TBL.2, REF.26
Pub. Country;Japan
Language;Japanese
Abstract;Staphylococcus aureus frequently colonizes the eczematous skin of patients with atopic dermatitis (AD) and is thought to be an important precipitaing factor of AD. The mechanism of worsening AD by Saureus are thought to be that (1) superantigenic exotoxins act as superantigen and allergen, (2) cellular proteins of S aureus act as allergens, and (3) .ALPHA.-toxin and other cytolytic toxins directly destroy the skin tissue. These are the reason why elimination of S aureus is very important to treat AD. (author abst.)