Current Topics of Allergic Diseases. Chemokines and Eosinophils.
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Accession number;00A0456087
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| Title;Current Topics of Allergic Diseases. Chemokines and Eosinophils. |
| Author;
FUJISAWA TAKAO
(National Sanatorium Mie Hospital)
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Journal Title;Japanese Journal of National Medical Services
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Journal Code:F0707A
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ISSN:0021-1699
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VOL.54;NO.2;PAGE.73-78(2000)
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| Figure&Table&Reference;FIG.1, TBL.2, REF.43 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Over the past decade, a number of cytokines with chemoattractive properties (chemokines) have been identified. These molecules have been found to possess a vast range of functions as embyogenesis, hematopoiesis, and inflammation. Eosinophils, major effector cells in allergic inflammation, express a chemokine receptor, CCR3, and ligands for CCR3 induce various eosinophil functions. Of these ligands, eotaxin is the most important for eosinophils. Eotaxin expression is upregulated in tissue of allergic inflammation and the levels of its expression correlate with eosinophil infiltration and disease severity. Eotaxin is produced mainly by epithelial cells and fibroblasts under the control of Th2 cytokines (upregulation) and Th1 cytokines (inhibition). Eotaxin exhibits such pleiotropic functions as myelopoiesis, eosinophil mobilization from bone marrow, eosinophil-endothelial cell adhesion, degranulation, and superoxide generation. Thus, eotaxin may be a "key player" in pathogenesis of allergic diseases. (author abst.) |
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