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Accession number;00A0456089
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| Title;Current Topics of Allergic Diseases. Infection-induced Control of Atopic Disorders. |
| Author;
SHIMAZU SHIN'ICHIRO
(National Sanatorium Wakayama Hospital)
ENOMOTO TADAO
(Wakayama Red Cross Soc. Wakayama Medical Center, JPN)
SHIWAKAWA TARO
(Univ. Wales Swansea, Gbr)
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Journal Title;Japanese Journal of National Medical Services
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Journal Code:F0707A
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ISSN:0021-1699
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VOL.54;NO.2;PAGE.85-88(2000)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.9 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;One of the treatment strategies for atopic diseases is to downregulate the Th2 system by inducing a Th1 response, because Th1 and Th2 cytokines are thought to be mutually antagonistic. We reported that there was a strong association between tuberculin skin tests and atopic disorders. Positive tuberculin responses predicted a lower atopy, lower serum IgE level, and Th1 cytokine profiles. Hopkin showed the evidence that injection of SRL172 to patients with hay fever supprssed symptoms of lower respiratory tract. And oter studies reported that administrations of BCG or SRL172 suppressed Th2 system in OVA-sensitized mice. These findings suggest that BCG should be effective in modulating allergic responses and may provided a therapeutic approach for atopic disorders. (author abst.) |
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