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Accession number;00A0456090
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| Title;Current Topics of Allergic Diseases. DNA Vaccines. |
| Author;
TODA MASAKO
(National Inst. Infectious Diseases, JPN)
SAKAGUCHI MASAHIRO
(National Inst. Infectious Diseases, JPN)
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Journal Title;Japanese Journal of National Medical Services
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Journal Code:F0707A
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ISSN:0021-1699
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VOL.54;NO.2;PAGE.89-93(2000)
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| Figure&Table&Reference;FIG.3, REF.26 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;DNA vaccination is a novel immunization technique to induce antigen-specific immune responses. This method is recognaized as an attractive approach not only for the vaccines of infectious disease, but for treatment of cancer, autoimmune diseases and allergic diseases. Induction of allergen-specific Th1 cells by inoculation with plasmid DNA encoding gene of the sensitizing allergens suppresses the activity of Th2 cells, which would be promising for interfering with the allergic reaction. It has become apparent that immune responses induced by DNA vaccination can be manipulated by altering the condition such as inculating method or route, or coadministering adjuvant or plasmid DNA encoding gene of costimulatory molecules. In this review, we discuss the potential of DNA vaccination for the treatment of allergic diseases, including recent knowledge. (author abst.) |
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