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Accession number;00A0470793
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| Title;T-cell Lymphoproliferative Disorder Involving the Central Nervous System in Two Cases. |
| Author;
INOHA SATOSHI
(Kyushu Univ., Grad. Sch.)
INAMURA TAKANORI
(Kyushu Univ., Grad. Sch.)
OGA SHOICHI
(Kyushu Univ., Grad. Sch.)
HARA TOSHIRO
(Kyushu Univ., Grad. Sch.)
FUKUI MASASHI
(Kyushu Univ., Grad. Sch.)
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Journal Title;Neurol Surg
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Journal Code:Z0684A
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ISSN:0301-2603
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VOL.28;NO.5;PAGE.435-439(2000)
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| Figure&Table&Reference;FIG.4, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Lymphoproliferative disorder (LPD) sometimes occurs in immunosuppressive patients. B-cell proliferation is, predominantly seen in patients with LPD and T-cell proliferation is rare. We here report two patients with T-cell LPD involving the central nervous system (CNS). A 7-year-old boy developed increased intracranial pressure and computed tomography showed a ring-enhanced mass lesion in the right frontal lobe. A 10-year-old boy developed gait disturbance and magnetic resonance imaging showed a non-enhanced lesion in the left parietal lobe. Radiological findings could not differentiate CNS-LPD from other intracranial diseases. Only histologic examination could diagnose LPD in both cases, and Epstein-Barr virus associated RNA was found in the infiltrated T-cell of the latter case. Although chemotherapy with antitumor agents was effective for remission of LPD in both cases, both patients died 3 years after their operations. As CNS-LPD shows rapid progression and frequently results in fatality, this disease requires immediate histologic diagnosis followed by extensive chemotherapy. (author abst.) |
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