Bacterial xenobiotic (antibiotic) efflux proteins and antibiotic resistance.
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Accession number;00A0771313
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| Title;Bacterial xenobiotic (antibiotic) efflux proteins and antibiotic resistance. |
| Author;
GOTO NAOMASA
(Kyoto Pharm. Univ.)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.48;NO.7;PAGE.509-515(2000)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.42 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Both bacterial and eukaryotic cells typically contain energy-dependent efflux proteins for self-defense against penetration by toxic compounds (xenobiotics), including antimicrobial and anticancer agents, into the cells. These resistance efflux proteins have been divided into two categories, ATP-dependent and proton-dependent, based on their energy sources. In bacteria, the proton-dependent efflux proteins have been found more frequently rather than ATP-dependent efflux proteins. Comparative amino acid sequence analysis of bacterial proton-dependent efflux proteins has enabled identification of three distinct families and superfamilies: a small multidrug resistance (SMR) family, a major facilitator superfamily (MFS), and a resistance-nodulation-cell division (RND) family. Most efflux proteins typically deal with a narrow range of structurally related substrates; for example, the Escherichia coli tetracycline exporter TetA. However, efflux proteins (multidrug efflux proteins) that can clearly handle a wide range of structurally dissimilar compounds have also been identified, and they may contribute to cross resistance between a wide variety of antimicrobial agents. Investigation of the mechanisms of resistance of Pseudomonas aeruginosa to quinolones and .BETA.-lactams has demonstrated interplay between efflux proteins and other resistance factors. (author abst.) |
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