Evaluation by Etest of the antimicrobial activity of beta-lactam antibiotics against clinical isolates.
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Accession number;00A0771315
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| Title;Evaluation by Etest of the antimicrobial activity of beta-lactam antibiotics against clinical isolates. |
| Author;
ISHII YOSHIKAZU
(Toho Univ., Sch. of Med.)
MA L
(Toho Univ., Sch. of Med.)
YAMAGUCHI KEIZO
(Toho Univ., Sch. of Med.)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.48;NO.7;PAGE.524-530(2000)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A nationwide epidemiological survey of the susceptibility of clinical isolates to beta-lactam antibiotics including cefepime was performed in order to assess the emergence of resistant strains in Japan. Susceptibility to 7 beta-lactam antibiotics, cefepime, cefpirome, ceftazidime, cefoperazone/sulbactam (C/S), imipenem, and piperacillin (for gram-negatives) or oxacillin (for gram-positives) , was studied in 22 medical centers, using a common protocol and method (Etest; AB BIODISK, Solna, Sweden). Inter- and intra-laboratcry variations were evaluated by analysis of quality control strains, and the results demonstrated good reproducibility. No strains resistant to any of these beta-lactams except for ceftazidime were found in Oxacillin-susceptible Staphylococcus aureus or coagulase-negative staphylococci. In Escherichia coli , 14.6% of the clinical strains were resistant to piperacillin, while only 0.5% were resistant to any of the other antibiotics. All clinical strains of Klebsiella spp. and Citrobacter freundii were susceptible to cefepime and imipenem. Isolates of Enterobacter spp, were most susceptible to imipenem (0.5% resistance) and cefepime (1.0%). Isolates of Serratia spp. were more susceptible to imipenem (4.5% resistance) and cefepime (5.0%) than to the other beta-lactam antibiotics tested. Only 0.5% of indole-positive Proteus were resistant to cefepime and ceftazidime. Isolates of Pseudomonas aeruginosa were more susceptible to cefepime (9.1% resistance) than to ceftazidime (11.4%), C/S (13.7%), piperacillin (20.1%), imipenem (22,4%), or cefpirome (27.9%). These results clearly indicate that emergence of strains resistant to cefepime is less of a problem than for the other beta-lactam antibiotics tested. (author abst.) |
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