|
Accession number;00A0771316
|
| Title;Penetration of levofloxacin into the buccal abscess in hypoproteinemic rats. |
| Author;
YAMASAKI TAKAHIRO
(Kobe Univ., Sch. of Med.)
YOSHII TAKASHI
(Hyogokenshokuinkenkokanrise)
OTSUKA YOSHIKI
(Kobe Univ., Sch. of Med.)
KOMORI TAKAHIDE
(Kobe Univ., Sch. of Med.)
|
Journal Title;Japanese Journal of Chemotherapy
|
Journal Code:F0608A
|
ISSN:1340-7007
|
|
VOL.48;NO.7;PAGE.531-534(2000)
|
| Figure&Table&Reference;FIG.2, TBL.1, REF.21 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The penetration of levofloxacin (10 mg/kg, p.o.) into the buccal abscess induced by carrageenin in hypoproteinemic rats was examined at different inflammatory stages (days 1 and 5) to clarify the influence of low serum albumin levels on pharmacokinetics of the inflammatory tissue concentrations. Both in normal and hypoproteinemic rats, the concentrations of the granulation tissue were equivalent to the serum levels. The Tmax of the granulation tissue and serum was faster in hypoproteinemic rats than that in normal rats. The Cmax of the granulation tissue and serum concentrations was also higher in hypoproteinemic rats than that in normal rats. This tendency was found in both inflammatory stages (days 1 and 5 after injection of carrageenin). These results may have been affected by the elevation of free antibiotics which were not bound to the serum albumin in hypoproteinemic rats. However, there were no differences between T1/2 in normal and hypoproteinemic rats. (author abst.) |
|
|
|
Related Articles;
|
