Study of penetration of parenteral antibiotics into human mandibular bone.
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Accession number;00A0771317
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| Title;Study of penetration of parenteral antibiotics into human mandibular bone. |
| Author;
YOSHII TAKASHI
(Hyogokenshokuinkenkokanrise)
YOSHIKAWA TOMOHIRO
(Kobe Univ., Sch. of Med.)
YOSHIOKA AYUMI
(Kobe Univ., Sch. of Med.)
FURUDOI SHUNGO
(Kobe Univ., Sch. of Med.)
NAKAO KAORU
(Kobe Univ., Sch. of Med.)
KOMORI TAKAHIDE
(Kobe Univ., Sch. of Med.)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.48;NO.7;PAGE.535-540(2000)
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| Figure&Table&Reference;FIG.5, TBL.3, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Penetration of five parenteral antibiotics (piperacillin (PIPC: 50 mg/kg, i.v.), cefazolin (CEZ: 30 mg/kg, i.v.), cefmetazole (CMZ: 16-22 mg/kg, d.i.v.), cefoperazone (CPZ: 20 mg/kg, d.i.v.), and latamoxef (LMOX: 15-24 mg/kg, d.i.v.)) into human mandibular bone after a single administration was determined. PIPC, CEZ, and CMZ levels in mandibular bone were higher than the respective MIC90 values of these drugs against Streptococcus sp., which is frequently isolated from patients with oral infections. These antibiotics should therefore be useful in treatment of mandibular osteomyelitis and prevention of postoperative infections. CPZ and LMOX levels did not reach the comparable MIC90 values against Streptococcus sp. in many patients, however, so the dosages for these antibiotics must be carefully considered. (author abst.) |
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