Structure and Properties of Members of the hGH Family. A Review.
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Accession number;00A0416103
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| Title;Structure and Properties of Members of the hGH Family. A Review. |
| Author;
()
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Journal Title;Endocr J
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Journal Code:F0625A
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ISSN:0918-8959
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VOL.47;NO.Supplement;PAGE.S1-S8(2000)
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| Figure&Table&Reference;FIG.1, REF.35 |
| Pub. Country;Japan |
| Language;English |
| Abstract;This review will summarize the properties of five variant forms of human growth hormone: a disulfide dimer, a glycosylated form, 20kD-hGH, and two peptides made up of portions of 22kD-hGH. The two pituitary peptides (hGH1-43 and hGH44-191) have, respectively, insulin-potentiating and anti-insulin properties. Both have been detected in serum. The shorter peptide may prove to be useful in decreasing the amount of exogenous insulin required by diabetics. The larger, strongly anti-insulin peptide, may be involved in diabetic retinopathy. We believe that this peptide is the long sought after diabetogenic substance of the pituitary gland. |
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