Cavernous Sinus Invasion and Tumor Proliferative Potential of Growth Hormone-Producing Pituitary Tumors.
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Accession number;00A0416119
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| Title;Cavernous Sinus Invasion and Tumor Proliferative Potential of Growth Hormone-Producing Pituitary Tumors. |
| Author;
IUCHI T
(Chiba Univ. School Of Medicine, Chiba, Jpn)
SAEKI N
(Chiba Univ. School Of Medicine, Chiba, Jpn)
UCHINO Y
(Chiba Univ. School Of Medicine, Chiba, Jpn)
HIGUCHI Y
(Chiba Univ. School Of Medicine, Chiba, Jpn)
TATSUNO I
(Chiba Univ. School Of Medicine, Chiba, Jpn)
NAKAMURA S
(Chiba Univ. School Of Medicine, Chiba, Jpn)
YASUDA T
(Chiba Univ. School Of Medicine, Chiba, Jpn)
YAMAURA A
(Chiba Univ. School Of Medicine, Chiba, Jpn)
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Journal Title;Endocr J
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Journal Code:F0625A
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ISSN:0918-8959
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VOL.47;NO.Supplement;PAGE.S77-S79(2000)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.7 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Purpose: Surgical removal of growth hormone-producing pituitary adenomas (GHomas) becomes difficult when they invade the cavernous sinus (CS). We investigated the relation among tumor proliferative potential, tumor volume and invasion of GHomas to CS. Materials & Methods: 15 patients with GHoma aged 20-59 years were enrolled. The volumes of the adenomas were calculated from MR images and the extension to CS was classified into 5 grades according to Knosp's grading system. The immuno-hisochemical staining for anti-Ki-67 monoclonal antibody (MIB-1) was performed and the proliferative potential of GHomas was determined as the percentage of MIB-1 labeled nuclei (MIB-1 index). The volume, MIB-1 index and pre-operative growth hormone (GH) level were compared with CS invasion by single and multiple regression analyses. Results: With single regression analyses, CS invasion was significantly correlated with both the volume (r=0.69, p<0.01) and MIB-1 index (r=0.73, p<0.01), but not with the GH level (r=0.42, p=0.12). The volume and MIB-1 index showed a weak correlation but it was not significant (r=0.52, p=0.06). With multiple regression analysis, CS invasion was well explained by the volume and MIB-1 index of GHomas (r=0.82, p<0.01). About 66% of CS invasion was explained by these two factors. Conclusions: In view of these results, not only the volume but also the speed of growth are important for GHomas to invade CS. GHomas with a high MIB-1 index may, even if they are small, more readily invade CS and need closer post-operative hormonal and neuroimaging studies. (author abst.) |
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