Functional Significance of Prop-1 Gene Expression in Pituitary Adenomas.
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Accession number;00A0416121
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| Title;Functional Significance of Prop-1 Gene Expression in Pituitary Adenomas. |
| Author;
USUI T
(Kyoto Univ. Graduate School Of Medicine, Kyoto, Jpn)
NAKAMURA Y
(Kyoto Univ. Graduate School Of Medicine, Kyoto, Jpn)
MIZUTA H
(Kyoto Univ. Graduate School Of Medicine, Kyoto, Jpn)
MURABE H
(Kyoto Univ. Graduate School Of Medicine, Kyoto, Jpn)
MURO S
(Kyoto Univ. Graduate School Of Medicine, Kyoto, Jpn)
TANAKA K
(Kyoto Univ. Graduate School Of Medicine, Kyoto, Jpn)
TANAKA I
(Kyoto Univ. Graduate School Of Medicine, Kyoto, Jpn)
SHIMATSU A
(Kyoto Univ. Graduate School Of Medicine, Kyoto, Jpn)
NAKAO K
(Kyoto Univ. Graduate School Of Medicine, Kyoto, Jpn)
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Journal Title;Endocr J
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Journal Code:F0625A
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ISSN:0918-8959
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VOL.47;NO.Supplement;PAGE.S85-S89(2000)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.19 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Prophet of Pit-1 (Prop-1), which is a paired-like homeodomain transcription factor, is capable of binding to sites in an early enhancer of the Pit-1 gene and regulating its expression. As human Pit-1 is expressed considerably in pituitary adenomas, we studied human Prop-1 gene expression in pituitary adenomas. We also sequenced the Prop-1 cDNAs in pituitary adenomas. Human Prop-1 transcript was detected in all pituitary adenomas examined by RT-PCR analysis. The expression of human Prop-1 in pituitary adenomas was confirmed by in situ hybridization in one of the GH-producing adenomas. The sequence analysis of human Prop-1 cDNAs in these pituitary adenomas revealed that there were no mutations except 5 silent nucleic acid substitutions, suggesting that mutations of Prop-1 gene do not represent a frequent mechanism of human pituitary tumorigenesis. (author abst.) |
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