Science Links Japan | Surveillance of susceptibility of clinical isolates of various bacterial species to antibacterial agents. No.1. Against gram-positive cocci and anaerobic bacteria isolated in 1998.

Surveillance of susceptibility of clinical isolates of various bacterial species to antibacterial agents. No.1. Against gram-positive cocci and anaerobic bacteria isolated in 1998.

Accession number;00A0829644

Title;Surveillance of susceptibility of clinical isolates of various bacterial species to antibacterial agents. No.1. Against gram-positive cocci and anaerobic bacteria isolated in 1998.

Author; KIMURA YOSHIJI (Shionogi & Co., Ltd, JPN) YOSHIDA ISAMU (Shionogi & Co., Ltd, JPN) HIGASHIYAMA ISAO (Shionogi & Co., Ltd, JPN) SASAKI SHIMARU (Shionogi & Co., Ltd.)

Journal Title;Japanese Journal of Chemotherapy

Journal Code:F0608A

ISSN:1340-7007

VOL.48;NO.8;PAGE.585-609(2000)

Figure&Table&Reference;TBL.21, REF.18

Pub. Country;Japan

Language;Japanese

Abstract;The activity of various antibacterial agents against clinical isolates of 919 strains of gram-positive cocci (22 species), and 170 strains of anaerobic bacteria (22 species) was assessed using agar-dilution MIC determination. The clinical isolates were isolated in 1998 at 14 facilities in Japan. Methicillin-resistant Staphylococcus aureus (MRSA) accounted for 51.7% of all S. aureus isolates. Vancomycin (VCM), teicoplanin (TEIC), arbekacin (ABK) and sulfamethoxazole-trimethoprim (ST) had the highest antibacterial activities against MRSA, with an MIC90 of 1.56 .MU.g/mL. VCM, ABK, minocycline and cefotiam were effective Staphylococcus epidermidis (MIC90.LEQ.3.13 .MU.g/mL). Penicillin (PC)-intermediate and PC-resistant Streptococcus peumoniae (PISP+PRSP) accounted for 46.8% of all S. pneumoniae strains. Cefpirome, cefoselis, carbapenems (CBPs), tosufloxacin, TEIC and VCM displayed the highest antibacterial activities against PISP+PRSP, inhibiting all strains at less than 0.39 .MU.g/mL. VCM and TEIC were effective against Ertterococcus faecalis and Enterococcus faecium (MIC90.LEQ.3.13 .MU.g/mL) . No VCM-resistant strains were found in any of the gram-positive cocci isolates tested, including MRSA and Ertterococcus species. However, TEIC-resistant strains of Staphylococcus haemolyticus and other cocci were present. Regarding the anaerobes, cefcapene exhibited the highest antibacterial activity against Peptostreptococcus spp., while VCM and benzylpenicillin were effective against Clostridium difficile, and S-1090 was effective against Propionibacterium acnes. CBPs, faropenem (FRPM) and flomoxef exhibited the highest antibacterial activity against the Bacteroides fragilis group and Prevotella spp.. CBPs and FRPM were potent antibacterial inhibitors for all anaerobic bacteria. However, the reduction in susceptibility of B. fragilis to CBPs should be noted. (author abst.)

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