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Accession number;00A0829647
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| Title;Pharmacokinetics of pazufloxacin injection in patients with reduced renal function. |
| Author;
ISHIDA YUICHIRO
(Kanagawa Prefect. Hosp. Affil. to Prefect. Nurses Sch.)
SAKURAI IWAO
(Kanagawa Prefect. Hosp. Affil. to Prefect. Nurses Sch.)
OKAMOTO HIDEKAZU
(Kanagawa Prefect. Hosp. Affil. to Prefect. Nurses Sch.)
TAKAHASHI TAKAYUKI
(Kanagawa Prefect. Hosp. Affil. to Prefect. Nurses Sch.)
MORITA MASAYUKI
(Kanagawa Prefect. Hosp. Affil. to Prefect. Nurses Sch.)
MATSUMOTO FUMIO
(Kanagawa Prefect. Hosp. Affil. to Prefect. Nurses Sch.)
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Journal Title;Japanese Journal of Chemotherapy
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Journal Code:F0608A
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ISSN:1340-7007
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VOL.48;NO.8;PAGE.645-653(2000)
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| Figure&Table&Reference;FIG.7, TBL.7, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The pharmacokinetics of pazufloxacin (PZFX) were evaluated in patients with reduced renal function. The optimum administration interval was examined, and the ability of hemodialysis to remove PZFX from the bloodstream was assessed. In patients with reduced renal function (aged, 37 to 58 years), 300 mg of PZFX was administered by drip intravenous injection (d.i.v.) over a period of 30 minutes. The serum and urinary levels of the drug were then determined at specific time intervals. The pharmacokinetic parameters were calculated, and changes in the serum level of PZFX following repeated administrations, were predicted. In some patients, hemodialysis was started 24 hours after the administration of PZFX, and the serum level of PZFX was determined after 4 hours of hemodialysis to assass the rate at which PZFX was removed. Elimination half-lives (T1/2.BETA.) and areas under the serum concentration-time curve from time zero to infinity (AUC0-inf) increased as the degree of renal function decreased. In particular, the T1/2.BETA. was 20 hours or longer in patients receiving hemodialysis. This value is much larger than the T1/2.BETA. value of healthy subjects (about 2 hours). Renal clearance also showed signs of reduction in patients with reduced renal function, suggesting a delay in urinary excretion. PZFX was removed from the blood by hemodialysis relatively easy; the apparent half-life of PZFX during hemodialysis was 2.78-4.00 hours. This value is about one sixth of the value during non-dialysis periods. About 59-66 mg of the administered PZFX was eliminated from the blood after 4 hours of hemodialysis. The pharmacokinetics of PZFX after repeated administration was simulated in individual patients using the experimental data. In the patients with a creatinine clearance (Ccr) value of 44.7 and 13.6 mL/min, 300 mg of PZFX could be safely administered twice daily with no adjustments to the administration interval necessary.... (author abst.) |
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