Recent Advances in Research of Multiple Myeloma.
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Accession number;00A0678470
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| Title;Recent Advances in Research of Multiple Myeloma. |
| Author;
TOGAWA ATSUSHI
(Kofu National Hospital)
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Journal Title;Japanese Journal of National Medical Services
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Journal Code:F0707A
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ISSN:0021-1699
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VOL.54;NO.6;PAGE.258-264(2000)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.36 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Recent advances in understanding of pathogenesis, biology and treatment of multiple myeloma (MM) were overviewed. To assess deregulated gene expression of IL 6, transgenic mice were produced by introducing the human IL 6 cDNA fused with the human immunoglobulin heavy chain enhancer. Cultured dendritic cells generated from bone marrow of MM patients may be infected with Kaposi's sarcoma herpesvirus (KSHV) partially homologous with IL 6. From these results, IL 6 may not play the pathogenetic role in MM. IgH translocation were detected in 73% patients with plasma cell malignancies and variable proto-oncogenes were reported as translocation partners in MM. This may explain multi-step oncogene development in the pathogenesis of MM. In biology of MM, osteoclasts differentiate, activate and osteolyse relating with osteoblast and MM cells, stroma cell, various cytokines and chemokines participate in the circuit. Proteoglycanes are demonstrated to regulate MM cell adhesion and proliferation. "Total therapy" program designed by Barlogie et al (tandem autologous peripheral blood stem cell transplant PBSCT) maximized the chance of complete response and, eventually cure. Bisphosphonate and thalidomide are in topics now concerning about reduction of tumor burden and interference of tumor neovascularization. (author abst.) |
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