Effect of Trp-P-1 on the Growth of Cultured Rat Astrocytes.
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Accession number;00A0535465
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| Title;Effect of Trp-P-1 on the Growth of Cultured Rat Astrocytes. |
| Author;
TABUCHI M
(Yonezawa Women's Coll. Yamagata Prefecture, Yonezawa-shi, Jpn)
ITO J
(Nagoya City Univ., Nagoya-shi, Jpn)
ISHIDA T
(Yonezawa Women's Coll. Yamagata Prefecture, Yonezawa-shi, Jpn)
HOSONO A
(Shinshu Univ., Nagano-ken, Jpn)
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Journal Title;Anim Sci J
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Journal Code:F0902A
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ISSN:1344-3941
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VOL.71;NO.3;PAGE.305-307(2000)
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| Figure&Table&Reference;FIG.2, REF.10 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The effects of Trp-P-1 (3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole) on the growth of astrocytes were investigated by in vitro culture experiments supplemented with Trp-P-1. Cultured astrocytes were prepared from the brains of 18 days old fetuses of Wistar rats and were incubated in F-10 medium supplemented with fetal calf serum. The growth of astrocytes (9 * 104 cells) cultured with 10.MU.M Trp-P-1 was inhibited, and the numbers of astrocytes were significantly less than the control (in distilled water) at each time interval (P<0.01, P<0.05). When astrocytes were cultured with varying concentrations of Trp-P-1 for 7 days, the cell number deoreased in proportion to the increased dose of Trp-P-1. These results indicated that Trp-P-1 cail significantly inhibit the astrocytes development in in vitro culture and the inhibition was dose dependent. (author abst.) |
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