Effect of Melatonin on Sleep and the Rectal Temperature of Young Healthy Evening Types.
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Accession number;00A0952827
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| Title;Effect of Melatonin on Sleep and the Rectal Temperature of Young Healthy Evening Types. |
| Author;
SHIRAKAWA SHIN'ICHIRO
(Kurume Univ., Fac. of Med.)
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Journal Title;Kyushu Neuropsychiatry
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Journal Code:Z0180B
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ISSN:0023-6144
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VOL.46;NO.2;PAGE.61-68(2000)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Although both the hypnotic action and synchronizing action during the circadian phase and the hypothermic action of exogenous melatonin (MLT) have all been demonstrated, its physiological mechanism has yet to be fully explained. Opinions remain divided regarding its hypnotic action in particular, and it has yet to be elucidated as to whether its effect is the result of a direct action or an action that is mediated by circadlan phase changes and/or hypothermia. In this study, we examined the presence of the hypnotic effects of exogenous MLT along with its effect on the rectal temperature after the oral administration of a pharmacologically low dose of MLT (3 mg) 15 minutes before normal bedtime in subjects consisting of 7 young healthy evening types (age: 23.4.+-.1.5 years). As a result, even when exogenous MLT was administered at a pharmacologically low dose at night, when endogenous MLT is adequately secreted, both sleep latency and the number of instances of waking up after falling asleep tended to decrease, while the amount of stage 2 sleep increased significantly, however, no hypothermic action regarding the rectal temperature for changes in the circadian phase were observed. Based on these findings, exogenous MLT was thus suggested to have some direct hypnotic action on habitual night sleep, although the extent of this action is considered to be relatively weak. (author abst.) |
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