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Accession number;01A0214284
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| Title;Molecular conformational change depending on surface-pressure in mycolic acid monolayers studied by atomic force microscopy. |
| Author;
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Journal Title;Nippon Kagakkai Koen Yokoshu
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Journal Code:S0493A
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ISSN:0285-7626
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VOL.78th;NO.1;PAGE.3(2000)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Mycobacteria represented by M. tuberculosis has a characteristic that the cell envelope is coated by a hard wall consisted of mycolic acids. Molecular structure of mycolic acid is known to depend on bacterium species, but its physical property is almost unknown. In the present study, an .alpha.-mycolic acid isolated from MAI complex, that is one of the atypical acid-fast bacteria, was found to form a stable Langmuir film on water. The property of the monolayer as a function of surface-pressure was investigated by use of atomic formce microscopy. It was explicitly revealed that the molecule largely changed its molecular conformation with an increase of the surface pressure. (author abst.) |
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