Safety Evaluation of Topical Medicaments Developed for Treatment of Dry Skin.
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Accession number;01A0174055
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| Title;Safety Evaluation of Topical Medicaments Developed for Treatment of Dry Skin. |
| Author;
SUGIURA MARIKO
(Nagoya Univ., Sch. of Med.)
HAYAKAWA RITSUKO
(Nagoya Univ., Sch. of Med.)
KATO YOSHIMI
(Nagoya Univ., Sch. of Med.)
SUGIURA KEIJI
(Nagoya Univ., Sch. of Med.)
HASHIMOTO RIKA
(Nagoya Univ., Sch. of Med.)
OGAWA HIROSHI
(Nagoya Univ., Sch. of Med.)
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Journal Title;Skin Research
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Journal Code:Z0014B
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ISSN:0018-1390
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VOL.42;NO.Suppl.22;PAGE.41-45(2000)
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| Figure&Table&Reference;TBL.3, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We conducted a 48h closed patch testing with 6 topical medicaments developed for treatment of dry skin on 370 patients with skin diseases. The 6 topical medicaments were as follows: A) 10% urea cream, B) 10% urea in W/O ointment, C) 5000 unit vitamin A in O/W ointment, D) 10% urea ointment, E) 20% urea ointment and F) 8% seramide cream. The subjects composed of 253 cases pf atopic dermatitis (AD) and 117 cases of non atopic dermatitis (non-AD). The skin irritation index of A was 11.5 on AD and 14.1 on non-AD. B was 28.9 on AD and 28.6 on non-AD. C was 24.7 on AD and 15.4 on non-AD. D was 27.3 on AD and 22.7 on non-AD. E was 11.1 on AD and 6.9 on non-AD and F was 20.7 on AD and 12.0 on non-AD. We concluded that we have to select safety products for patients with AD by screening patch testing, because several moisturizing topical products have the possibility to irritate atopic skin. (author abst.) |
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