A Study on Drug-Induced Hypersensitivity Hepatic Injury by Leucocyte Migration Test.
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Accession number;01A0256081
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| Title;A Study on Drug-Induced Hypersensitivity Hepatic Injury by Leucocyte Migration Test. |
| Author;
ABE MANABU
(Suibarago Byoin)
UNO KATSUJI
(Suibarago Byoin)
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Journal Title;Japanese Journal of Hospital Pharmacy
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Journal Code:Y0888A
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ISSN:0389-9098
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VOL.27;NO.1;PAGE.5-14(2001)
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| Figure&Table&Reference;TBL.8, REF.44 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The identification of allergenic drugs was performed in 79 patients suspected of suffering from drug-induced hepatic injury using the leucocyte migration test (LMT). Moreover, the LMT was performed on the administered drugs in 35 patients who had been receiving drugs but had not yet manifested any allergic symptoms (patients without hypersensitivity to drugs). If either leucocyte migration activating factor (LMAF) or leucocyte migration inhibitory factor (LMIF) was detected in the LMT either with or without the patient's serum, then the test results were regarded as positive. The proportion of LMT positives was 67.1% in 79 patients suspected of suffering drug-induced hepatic injury and 8.6% in 35 patients without any such hypersensitivity to the drugs, and therefore the positive rate was significantly higher in the patients suspected of suffering drug-induced hepatic injury than in the patients without hypersensitivity to the drugs (p<0.0001, .CHI.2-test). The proportion of LMT positives was 45.6% for tests with the patient's serum and 46.8% for tests without the patient's serum, and there was no substantial difference in the LMT-positive rate between both tests. In addition, no substantial difference was observed among the four clinical types of hepatic injuries. In addition, LMAF was detected in 34.2% and LMIF in 38.0%, and no substantial difference was seen in the rate of detection between both factors. However, concomitant symptoms were observed in 34 cases (43.0%). The proportion of LMT positives was 82.4% in the cases with concomitant symptoms and 55.6% in those without concomitant symptoms. Accordingly, the proportion of LMT positives were significantly higher in the cases with concomitant symptoms than in those without concomitant symptoms (p<0.05, .CHI.2-test).... (author abst.) |
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